MISSION Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously. POSITION SUMMARY The Zone Director is a second-line field leader responsible for driving commercial performance, building 4 high-performing Region Business Director (RBD) teams, and ensuring execution excellence across the liver portfolio. This role translates national strategy into regional impact, with a strong emphasis on rare disease expertise, patient-centricity, and cross-functional leadership. Assigned Area: ME, NH, VT, NY, RI, MA, CT, NJ, PA, DE, MD, D.C., VA, OH, MI, IN, TN, NC, SC, GA, FL JOB FUNCTIONS/RESPONSIBILITIES Enterprise Leadership Own and deliver Zone business performance across the liver portfolio with a strategic, big-picture mindset Drive change and innovation Develop and execute zone-specific business plans aligned to national strategy Analyze market trends, competitive dynamics, and performance data to inform actions Team Leadership & Development Lead, coach, and develop first-line leaders to maximize team effectiveness Build a strong leadership pipeline and succession plans Foster a culture of accountability, engagement, and continuous improvement Execution Excellence Ensure consistent and high-quality execution of brand strategy in the field Monitor KPIs and drive disciplined performance management Identify and scale best practices across regions Cross-Functional Collaboration Partner with Marketing, Market Access, Medical Affairs, Patient Services and Operations Ensure alignment on strategy and coordinated execution Provide field insights to inform brand planning and lifecycle strategy Market & Customer Engagement Maintain strategic relationships with key opinion leaders (KOLs) and top accounts Understand regional nuances in referral patterns and treatment pathways Support teams in navigating complex access and reimbursement environments Compliance & Ethical Leadership Ensure all activities comply with regulatory, legal, and company policies Model integrity and patient-first decision making Reinforce a culture of compliance across the organization QUALIFICATIONS Education/Experience: Bachelor’s degree required; advanced degree preferred (MBA, etc.) 7+ years pharmaceutical/biotech experience, plus minimum of 5 years of leadership experience Successful experience leading leaders (second-line leadership) highly desired Significant rare disease and/or specialty experience Experience in rare liver disease a plus Proven success in product launches, ideally with first-in-class therapies and in competitive markets Demonstrated ability to build, lead, train and develop high-performing teams Proven success in sales leadership roles with the ability to inspire, influence and align teams Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and difficult access to therapies Strong leadership presence with the ability to inspire, influence, and align teams Strong understanding of market access, payer dynamics, and patient services Demonstrated ability to lead in a matrixed organization High integrity, ethical standards, and commitment to compliance Thrives in a fast-paced, dynamic, and collaborative environment Able to travel frequently, up to 70% overnight travel and has a valid drivers’ license #LI-REMOTE Mirum Pharmaceuticals is committed to Equal Employment Opportunity (EEO) and to compliance with all Federal, State and Local laws that prohibit employment discrimination on the basis of race, age, national origin, ethnicity, religion, gender, gender identity, pregnancy, marital status, sexual orientation, citizenship, genetic disposition or characteristics, disability, veteran’s status or any other classification protected by applicable State/Federal/Local laws. Mirum Pharmaceuticals provides reasonable accommodation for qualified individuals with disabilities and disabled veterans in job application procedures.