Note: The job is a remote job and is open to candidates in USA. Caribou Biosciences is a leading clinical-stage CRISPR genome-editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. The Senior Clinical Research Scientist II plays a key role in the clinical development of allogeneic CAR-T therapies for hematologic malignancies, leading study-level activities and contributing to clinical strategy.

Responsibilities

• Lead clinical study in execution, including planning, conduct, data review, and reporting for Phase I and II trials in hematologic malignancies
• Own ongoing clinical data review, ensuring patient safety and data integrity; identify trends and drive data informed decisions
• Lead safety monitoring activities including review of adverse events and CAR-T associated toxicities (ie: CRS, ICANS) and contribute to dose escalation decisions
• Drive cross-functional collaboration with Clinical Operations, Translational Sciences, Data Management, Biostatistics, Regulatory, and CMC teams to ensure high-quality study execution
• Lead authorship of key study documents, including protocols, Investigator’s Brochures, clinical study reports, regulatory documents, and safety narratives
• Integrate clinical and translational data (ie: cell expansion, persistence, biomarker data) to generate insights and inform program strategy
• Contribute to regulatory strategy and submissions, including IND-related documents and health authority responses
• Serve as a scientific lead at the study level, engaging with investigators, CROs, and key opinion leaders
• Support development of publications, abstracts, and presentations for scientific conferences
• Ensure compliance with GCP, internal SOPs, and regulatory requirements

Skills

• PhD/PharmD with 5+ years of experience in clinical development; MA/MS/MSN and 8+ years of experience; BA/BS/BSN and 10+ years of experience
• Experience in hematology-oncology drug development
• Experience with CAR-T or cell therapy development
• Demonstrated ownership of clinical studies, preferably early phase trials
• Strong scientific writing and communication skills
• Experience with GCP and regulatory requirements
• Experience with clinical data review and interpretation (including data listings)
• Ability to analyze and synthesize complex clinical and biomarker data
• Ability to travel 30% based on business needs
• Experience in fast paced biotech environment
• Experience with product launch or late stage development activities

Benefits

• Comprehensive compensation package, which includes competitive salary, bonus, and equity for all employees
• Generous paid vacation time, in addition to company-observed holidays
• Excellent medical, dental, and vision insurance
• 401(k) retirement savings plan, which includes matching employer contributions
• Employee stock purchase plan (ESPP)
• Tuition reimbursement program

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