Note: The job is a remote job and is open to candidates in USA. Pillar Biosciences is expanding its bioinformatics team focused on biostatistics, genomics, and next-generation sequencing. They are searching for a bioinformatics data scientist to improve PCR assays for high throughput genomic sequencing, collaborating with various teams to analyze and interpret sequencing data.

Responsibilities

• Work closely with software, experimental, regulatory, biological and clinical collaborators as a key member of the bioinformatics team in understanding assay performance
• Support the PCR primer/probe design. Identifies known and emerging nucleic acid biomarkers (SNV, InDel, DupDel, CNV, methylation, and fusions) via review of scientific papers and clinical trial summaries that drive treatment choices or are useful for monitor disease progression
• Analyze and interpret high-throughput internal DNA and RNA sequencing data from designed chemistry, with a specific focus on mutation identification and oncology characterization
• Improve biology/oncology understanding and assay performance based on the data

Skills

• MS with 3+ years of experience or PhD in genetics or related discipline
• Passionate about bioinformatics and data science
• Proven critical thinking capability with ability to follow through
• Proven understanding of both human genetics, oncology, and the genetic variation associated with various types of cancer
• Well versed with public sequence depositories of genome sequence and variation data, especially those focused on oncology and is able to query, retrieve, manipulate, and analyze data from these databases
• Experienced with the development of nucleic acid diagnostics based on the amplification of DNA and RNA via PCR
• Excellent communication (written and verbal) and data presentation skills
• Deep knowledge and experience analyzing NGS data on human genome, either from industry or academia
• Proficiency with standard NGS tools like bwa, samtools, bedtools, etc
• Experience working with somatic or low input DNA assays
• Experience and knowledge of commercially available of modern variant calling packages
• Proficient with excel or scripting language to analyze/understand NGS data

Company Overview

• Pillar Biosciences is a global innovator in next-generation sequencing (NGS), focused on delivering kitted NGS solutions designed for robust analytical performance and operational efficiency. It was founded in 2014, and is headquartered in Natick, Massachusetts, USA, with a workforce of 51-200 employees. Its website is http://www.pillar-biosciences.com.

Company H1B Sponsorship

• Pillar Biosciences Incorporated has a track record of offering H1B sponsorships, with 3 in 2024, 1 in 2022, 3 in 2021. Please note that this does not guarantee sponsorship for this specific role.